Efficient synthesis of diversely substituted pyrimidines by palladium catalyzed Suzuki-Miyaura coupling

作者：Faldu Viral J; Talpara Pratik K; Shah Viresh H^*

来源：Tetrahedron Letters, 2014, 55(8): 1456-1460.

DOI：10.1016/j.tetlet.2014.01.042

• Suzuki-Miyaura coupling
• Palladium catalyst
• Triphenylphosphine

An efficient synthesis of 2-aryl/heteroaryl substituted pyrimidinyl ethanones 4(a-t) was developed using a palladium-catalyzed Suzuki-Miyaura coupling reaction strategy. Use of Pd(OAc)(2) in the presence of PPh3 and Na2CO3 in 1,4-dioxane solvent was found to be the most effective reaction condition.

• 出版日期2014-2-19