DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention

作者：Gautam Swetlana; Roy Subhadeep; Ansari Mohd Nazam; Saeedan Abdulaziz S; Saraf Shubhini A; Kaithwas Gaurav^*

来源：Breast Cancer, 2017, 24(2): 180-190.

DOI：10.1007/s12282-016-0723-2

• Angiogenesis
• Apoptosis
• Cyclooxygenase
• Lipoxygenase
• NSAIDs
• Proliferation

Cancer is a leading cause of death and major health concern worldwide. The animal and human studies support the presumption that inflammation directs the cancer initiation and progression. Cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) are the key players in the inflammatory cascade contributing towards the angiogenesis, tumor cell invasiveness, and disruption in the pathways of cellular proliferation/apoptosis. Contemporary studies have particularized a promising role of COX-2 and 5-LOX inhibitors in cancer chemoprevention. The present review is a pursuit to define implications of dual COX-2 and 5-LOX (DuCLOX-2/5) inhibition on various aspects of cancer augmentation and chemoprevention.

• 出版日期2017-3