Nanoparticles made from novel starch derivatives for transdermal drug delivery

作者：Santander Ortega M J; Stauner T; Loretz B; Ortega Vinuesa J L; Bastos Gonzalez D; Wenz G; Schaefer U F; Lehr C M^*

来源：Journal of Controlled Release, 2010, 141(1): 85-92.

DOI：10.1016/j.jconrel.2009.08.012

• Starch
• Nanoparticles
• Physico-chemical Characterization
• Drug delivery
• Skin

The goal of this paper was aimed to the formulation of nanoparticles by using two different propyl-starch derivatives - referred to as PS-1 and PS-1.45 - with high degrees of substitution: 1.05 and 1.45 respectively. A simple o/w emulsion diffusion technique, avoiding the use of hazardous solvents such as dichloromethane or dimethyl sulfoxide, was chosen to formulate nanoparticles with both polymers, producing the PS-1 and PS-1.45 nanoparticles. Once the nanoparticles were prepared, a deep physicochemical characterization was carried out, including the evaluation of nanoparticles stability and applicability for lyophilization. Depending on this information, rules on the formation of PS-1 and PS-1.45 nanoparticles could be developed. Encapsulation and release properties of these nanoparticles were studied, showing high encapsulation efficiency for three tested drugs (flufenamic acid, testosterone and caffeine); in addition a close to linear release profile was observed for hydrophobic drugs with a null initial burst effect. Finally, the potential use of these nanoparticles as transdermal drug delivery systems was also tested, displaying a clear enhancer effect for flufenamic acid.

• 出版日期2010-1-4