A rhodamine derivative for Hg2+-selective colorimetric and fluorescent sensing and its application to in vivo imaging

作者:Li, Xue-Mei; Zhao, Rui-Rui; Wei, Yu-Ling; Yang, Dan; Zhou, Zhang-Jian; Zhang, Jun-Feng*; Zhou, Ying*
来源:Chinese Chemical Letters, 2016, 27(6): 813-816.
DOI:10.1016/j.cclet.2016.04.001

摘要

A rhodamine-based sensor has been developed for the detection of mercuric ions. The colorimetric and fluorescence responses, allowing naked-eye detections, are based on Hg2+-induced opening of the rhodamine spirocycle. Among all the testes ions, only Hg2+ generated a significant fluorescence enhancement of up to 300-fold, with a bright yellow-green emission. This sensor was a low toxic compound, and was successfully applied in the in vivo imaging of Hg2+ in Spill 2 cells and C. elegans. This approach provides a sensitive and accurate method for the estimation of Hg2+ in environmental, tobacco and biological applications.