Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones

作者：Sehout Imene; Boulcina Raouf; Boumoud Boudjemaa; Berree Fabienne; Carboni Bertrand; Debache Abdelmadjid^*

来源：Letters in Organic Chemistry, 2013, 10(7): 463-467.

• Multicomponent reaction
• one-pot synthesis
• Biginelli reaction
• 3, 4dihydropyrimidin-2(1H)-ones/thiones
• ascorbic acid

An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 degrees C to afford the desired products in moderate to good yields.

• 出版日期2013-8