Neutrophil Depletion Suppresses Pulmonary Vascular Hyperpermeability and Occurrence of Pulmonary Edema Caused by Hantavirus Infection in C.B-17 SCID Mice

作者：Koma Takaaki; Yoshimatsu Kumiko; Nagata Noriyo; Sato Yuko; Shimizu Kenta; Yasuda Shumpei P; Amada Takako; Nishio Sanae; Hasegawa Hideki; Arikawa Jiro^*

来源：Journal of Virology, 2014, 88(13): 7178-7188.

DOI：10.1128/JVI.00254-14

Hantavirus infections are characterized by vascular hyperpermeability and neutrophilia. However, the pathogenesis of this disease is poorly understood. Here, we demonstrate for the first time that pulmonary vascular permeability is increased by Hantaan virus infection and results in the development of pulmonary edema in C. B-17 severe combined immunodeficiency ( SCID) mice lacking functional T cells and B cells. Increases in neutrophils in the lung and blood were observed when pulmonary edema began to be observed in the infected SCID mice. The occurrence of pulmonary edema was inhibited by neutrophil depletion. Moreover, the pulmonary vascular permeability was also significantly suppressed by neutrophil depletion in the infected mice. Taken together, the results suggest that neutrophils play an important role in pulmonary vascular hyperpermeability and the occurrence of pulmonary edema after hantavirus infection in SCID mice.

• 出版日期2014-7