Application of a Raney-Cobalt-Mediated Tandem Reductive Cyclization Protocol to Total Syntheses of the Aspidosperma Alkaloids (+/-)-Limaspermidine and (+/-)-1-Acetylaspidoalbidine

作者：Tan Shen H; Banwell Martin G^*; Willis Anthony C; Reekie Tristan A

来源：Organic Letters, 2012, 14(22): 5621-5623.

DOI：10.1021/ol3026846

The racemic modification of the Aspidosperma alkaloid limaspermidine (1) has been prepared in ten steps including one involving a Raneycobalt-mediated tandem reductive cyclization of nitrile 8 to give the tetracyclic system 9b. Compound (+/-)-1 has been converted over two steps into (+/-)-1-acetylaspidoalbidine [(+/-)-13].

• 出版日期2012-11-16