A rhodium(I)-catalyzed demethylation-cyclization of o-anisole-substituted ynamides in the synthesis of chiral 2-amido benzofurans

作者：Oppenheimer Jossian^*; Johnson Whitney L; Tracey Michael R; Hsung Richard P; Yao Pei Yuan; Liu Renhe; Zhao Kang

来源：Organic Letters, 2007, 9(12): 2361-2364.

DOI：10.1021/ol0707362

A Rh(I)-catalyzed demethylation-cyclization sequence for a direct transformation of o-anisole-substituted ynamides to benzofurans is described here. The Ag salt functions synergistically with Rh(I) for the key demethylation step.

• 出版日期2007-6-7
• 单位天津大学