A Comparative Interaction between Copper Ions with Alzheimer%26apos;s beta Amyloid Peptide and Human Serum Albumin

作者：Behbehani G Rezaei^*; Barzegar L; Mohebbian M; Saboury A A

来源：Bioinorganic Chemistry and Applications, 2012, 208641.

DOI：10.1155/2012/208641

The interaction of Cu2+ with the first 16 residues of the Alzheimer%26apos;s amyliod beta peptide, A beta(1-16), and human serum albumin (HSA) were studied in vitro by isothermal titration calorimetry at pH 7.2 and 310 K in aqueous solution. The solvation parameters recovered from the extended solvation model indicate that HSA is involved in the transport of copper ion. Complexes between A beta(1-16) and copper ions have been proposed to be an aberrant interaction in the development of Alzheimer%26apos;s disease, where Cu2+ is involved in A beta(1-16) aggregation. The indexes of stability indicate that HSA removed Cu2+ from A beta(1-16) rapidly, decreased Cu-induced aggregation of A beta(1-16), and reduced the toxicity of A beta(1-16) + Cu2+ significantly.

• 出版日期2012