A pharmacokinetic comparison of two voriconazole formulations and the effect of CYP2C19 polymorphism on their pharmacokinetic profiles

作者：Chung Hyewon; Lee Howard; Han HyeKyung; An Hyungmi; Lim Kyoung Soo; Lee YongJin; Cho Joo Youn; Yoon Seo Hyun; Jang In Jin; Yu Kyung Sang^*

来源：Drug Design, Development and Therapy, 2015, 9: 2609-2616.

DOI：10.2147/DDDT.S80066

• voriconazole
• pharmacokinetics
• pharmacogenetics
• CYP2C19

Purpose: SYP-1018 is a lyophilized polymeric nanoparticle formulation of voriconazole that is under development for intravenous dosing. This study compared the pharmacokinetic and tolerability profiles of SYP-1018 with those of Vfend (R), the marketed formulation of voriconazole. The effect of CYP2C19 polymorphism on the voriconazole pharmacokinetics was also evaluated.
Methods: An open-label, two-treatment, two-period, two-sequence crossover study was conducted in 52 healthy male volunteers, who randomly received a single intravenous infusion of either of the two voriconazole formulations at 200 mg. Blood samples were collected up to 24 hours after drug administration for pharmacokinetic analysis. The plasma concentrations of voriconazole were determined using liquid chromatography with tandem mass spectrometry, and the pharmacokinetic parameters were estimated using a noncompartmental method. CYP2C19 genotype was identified in 51 subjects.
Results: The geometric mean ratio (90% confidence interval) of SYP-1018 to Vfend (R) was 0.99 (0.93-1.04) for the maximum plasma concentrations (C-max) and 0.97 (0.92-1.01) for the area under the concentration-time curve (AUC) from dosing to the last quantifiable concentration (AUC(last)). Nineteen homozygous extensive metabolizers (EMs, *11), 19 intermediate metabolizers (IMs, *12 or *13), and ten poor metabolizers (PMs, *22, *23, or *33) were identified, and the pharmacokinetic comparability between SYP-1018 and Vfend (R) was also noted when analyzed separately by genotype. The systemic exposure to voriconazole was greatest in the PM group, followed by the IM, and then the EM groups. Furthermore, the intra-subject variability for C-max and AUC(last) was greater in IMs and PMs than in EMs. No serious adverse event occurred, and both treatments were well tolerated.
Conclusion: SYP-1018 had comparable pharmacokinetic and tolerability profiles to Vfend (R) after a single intravenous infusion. CYP2C19 genotype affected not only the pharmacokinetics of voriconazole, but its intrasubject variability. SYP-1018 can be further developed as a clinically effective alternative to Vfend (R).

• 出版日期2015