A Tale of Two Pathways: Renewing the Promise of Anti-CD40L Blockade

作者:Thomson A W*; Ezzelarab M B
来源:American Journal of Transplantation, 2017, 17(5): 1156-1157.
DOI:10.1111/ajt.14217

摘要

A new Fc-silent anti-human CD154 domain antibody synergizes with conventional immunosuppressants to control renal transplant rejection in nonhuman primates without evidence of thromboembolism, raising the prospect of its combination with approved costimulation-blocking agents in the clinic. See the article from Kim etal on page 1182.

  • 出版日期2017-5