Dihalogenated sulfanilamides and benzolamides are effective inhibitors of the three beta-class carbonic anhydrases from Mycobacterium tuberculosis

作者：Maresca Alfonso; Scozzafava Andrea; Vullo Daniela; Supuran Claudiu T^*

来源：Journal of Enzyme Inhibition and Medicinal Chemistry, 2013, 28(2): 384-387.

DOI：10.3109/14756366.2011.645539

• Carbonic anhydrase
• beta-carbonic anhydrase
• sulfonamide
• dihalogenated sulfanilamide/benzolamide
• enzyme inhibitor
• Mycobacterium tuberculosis

A series of halogenated sulfanilamides and halogenated benzolamide derivatives have been investigated as inhibitors of three beta-carbonic anhydrases (CAs, EC 4.2.1.1) from the bacterial pathogen Mycobacterium tuberculosis, mtCA 1 (Rv1284), mtCA 2 (Rv3588c) and mtCA 3 (Rv3273). All three enzymes were inhibited with efficacies between the submicromolar to the micromolar one, depending on the substitution pattern at the sulfanilamide moiety/fragment of the molecule. Best inhibitors were the halogenated benzolamides (K(I)s in the range of 0.12-0.45 mu M) whereas the halogenated sulfanilamides were slightly less inhibitory (K(I)s in the range of 0.41-4.74 mu M). This class of beta-CA inhibitors may have the potential for developing antimycobacterial agents with a diverse mechanism of action compared to the clinically used drugs for which many strains exhibit multi-drug/extensive multi-drug resistance.

• 出版日期2013-4