An efficient and facile multicomponent synthesis of 4,6-diarylpyridine derivatives under solvent-free conditions

作者：El Sayed Hassan A^*; Ouf Nabil H; Moustafa Ahmed H

来源：Research on Chemical Intermediates, 2014, 40(1): 407-412.

DOI：10.1007/s11164-012-0972-4

• Multicomponent synthesis
• Solvent-free conditions
• Pyridine-3-carbonitrile

We present an efficient and facile synthesis of 4,6-diaryl-2-oxo-1,2-dihydropyridine-3-carbonitriles (5a-j) via a four-component system of aromatic aldehydes (1), acetophenones (2), ethyl cyanoacetate (3), and ammonium acetate (4). The short reaction time coupled with the simplicity of the reaction procedure and clean reaction make this method one of the most efficient methods for synthesis of this class of compounds.

• 出版日期2014-1