A Method for Synthesis of Homoallylic Bromide

作者:Qi Wenke; Wang Peipei; Fan Liyuan; Zhang Songlin*
来源:Journal of Organic Chemistry, 2013, 78(12): 5918-5924.
DOI:10.1021/jo400580n

摘要

Cyclopropyl Grignard reagents react with carbonyl compounds in the presence of diethyl phosphite to give homoallylic bromides. The reaction is effectively carried out under mild conditions in a one-pot fashion with moderate to good yields.

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