Allium tuberosum: Antidiabetic and hepatoprotective activities

作者：Tang, Xingli; Olatunji, Opeyemi J.; Zhou, Yifeng; Hou, Xilin^*

来源：Food Research International, 2017, 102: 681-689.

DOI：10.1016/j.foodres.2017.08.034

• Antidiabetic
• Hepatoprotective
• Allium tuberosum
• Carbon tetrachloride
• Antioxidant
• Flavonoids

Allium tuberosum (AT) is traditionally used for treating nocturnal emissions, abdominal pain, diarrhea, sexual dysfunction and asthma. This study aimed at investigating the antidiabetic and hepatoprotective activities of the butyl alcohol fraction from the methanolic extract of A. tuberosum. For the antidiabetic activity, rats were induced with diabetes by intraperitoneal injection of 150 mg/kg alloxan and treated for 30 days with AT extract (100, 200 and 400 mg/kg). Animals were sacrificed after the study and the fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), HDL, malondialdehyde (MDA) catalase, superoxide dismutase and glutathione levels were determined. The hepatoprotective assay, mice were pretreated for seven days with AT (100, 200 and 400 mg/kg) and silymarin (100 mg/kg or). Thereafter 10 ml/kg of 2% v/v CCl4 was administered intraperitoneally on the 7th day to induce acute liver injury. Blood and liver samples were obtained and serum enzymes ALT, AST, ALP, SOD, GSH, CAT, MDA and pro-inflammatory mediators were assessed. AT significantly decrease FBG, serum TG, TC, MDA levels and significant increased HDL, SOD, GSH and CAT activities in the diabetic rats. In addition, AT significantly inhibited MDA, IL-1b, IL-6 and TNF-alpha levels and prevented the depletion of the antioxidant enzymes GSH, SOD and CAT activities in CCl4 induced liver damage. Furthermore, AT markedly reduced AST, ALT and ALP levels in the CCl4 treated mice groups. In conclusion, the antidiabetic and hepatoprotective effect of AT may be associated with its antioxidant and its ability to inhibit the pro-inflammatory mediators.

• 出版日期2017-12
• 单位南京农业大学; 江苏省中国科学院植物研究所