Micronization of fenofibrate by rapid expansion of supercritical solution

作者：Hiendrawan Stevanus; Veriansyah Bambang; Tjandrawinata Raymond R^*

来源：Journal of Industrial and Engineering Chemistry, 2014, 20(1): 54-60.

DOI：10.1016/j.jiec.2013.04.027

• Fenofibrate
• RESS
• Particle size

Micronization of fenofibrate was investigated using rapid expansion of supercritical solution (RESS) process. Effects of pressure, temperature and nozzle on particle size were optimized using Taguchi's orthogonal array and analyzed using XRD, DSC, FT-IR, SEM, laser diffractometer and dissolution testing. Processed fenofibrate retained crystalline structure and has a similar chemical structure with unprocessed fenofibrate. The average particle size of fenofibrate was reduced from its original 68.779 +/- 0.146 mu m to 3.044 +/- 0.056 mu m under the optimum condition (T at 35 degrees C, Pat 200 bar and nozzle diameter at 200 mu m). The processed fenofibrate showed an enhanced dissolution rate by 8.13 times.

• 出版日期2014-1-25