A Mn(II) complex of boradiazaindacene (BODIPY) loaded graphene oxide as both LED light and H2O2 enhanced anticancer agent

作者：Xu, Xiao-Lei; Shao, Jian; Chen, Qiu-Yun^*; Li, Cheng-Hao; Kong, Meng-Yun; Fang, Fang; Ji, Ling; Boison, Daniel; Huang, Tao; Gao, Jing; Feng, Chang-Jian

来源：Journal of Inorganic Biochemistry, 2016, 159: 1-6.

DOI：10.1016/j.jinorgbio.2016.02.007

• Manganese
• Cancer
• H2O2-activatable
• Photodynamic
• Graphene

Cancer cells are more susceptible to H2O2 induced cell death than normal cells. H2O2-activatable and O-2-evolving nanoparticles could be used as photodynamic therapy agents in hypoxic environments. In this report, a photo active Mn(II) complex of boradiazaindacene derivatives (Mn-1) was used as a dioxygen generator under irradiation with LED light in water. Moreover, the in vitro biological evaluation for Mn-1 and its loaded graphene oxide (herein called Mn-1@GO) on HepG-2 cells in normal and hypoxic conditions has been performed. In particular, Mn-1@GO can react with H2O2 resulting active anticancer species, which show high inhibition on both HepG-2 cells and CoCl2-treated HepG-2 cells (hypoxic cancer cells). The mechanism of LED light enhanced anticancer activity for Mn-1@GO on HepG-2 cells was discussed. Our results show that Mn(II) complexes of boradiazaindacene (BODIPY) derivatives loaded GO can be both LED light and H2O2-activated anticancer agents in hypoxic environments.

• 出版日期2016-6
• 单位江苏大学