Association of the cell death-inducing DNA fragmentation factor alpha-like effector A (CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population

作者：Zhang, Ling; Dai, Ying; Bian, Lili; Wang, Wei; Wang, Wei; Muramatsu, Masaaki^*; Hua, Qi

来源：Diabetes Research and Clinical Practice, 2011, 91(2): 233-238.

DOI：10.1016/j.diabres.2010.10.016

• CIDEA
• Polymorphism
• Metabolic syndrome
• Obesity
• Hypertension

Aims: The CIDEA gene is involved in energy metabolism and a non-synonymous single nucleotide polymorphism (SNP), V115F (G/T), is a risk factor for obesity in Swedish subjects and metabolic syndrome (MetS) in Japanese subjects. However, the risk allele was a G in Swedish subjects and a T in Japanese subjects. The present study investigated the association between this SNP and MetS in a Chinese population. @@@ Methods: Three hundred and fifty-one subjects evaluated at the Cardiac Clinic in Xuanwu Hospital for MetS risks were recruited. Anthropometric measurements, blood pressure, fasting bloodglucose, andbloodlipid levels were determined in addition to the polymorphism. @@@ Results: The proportion of subjects with MetS was significantly higher based on genotype, in the order: GG < GT < TT (p = 0.003). In multiple logistic regression analysis, the odds ratios for MetS in the GT and TT genotypes, compared to the referent GG genotype, were 2.26 (p = 0.003) and 2.89 (p = 0.002), respectively. Similar trends were observed for the related phenotypes of central obesity (GT: OR = 2.20, p = 0.004; TT: OR = 3.31, p = 0.002) and dyslipidemia (GT: OR = 1.73, p = 0.047; TT: OR = 2.10, p = 0.03). @@@ Conclusions: The T allele of the CIDEA V115F SNP is a risk factor for MetS and its related phenotypes in a Chinese population. # 2010 Elsevier Ireland Ltd.

• 出版日期2011-2
• 单位首都医科大学