Association Study of Xenobiotic Detoxication and Repair Genes with Malignant Brain Tumors in Children

作者：Salnikova L E; Zelinskaya N I; Belopolskaya O B; Aslanyan M M; Rubanovich A V^*

来源：Acta Naturae, 2010, 2(4): 58-65.

• gene polymorphism
• malignant brain tumors in children
• genes of xenobiotic detoxication
• DNA repair genes

This study presents the results of research on DNA polymorphism in children with malignant brain tumors (172 patients, 183 in the control group). Genotyping was performed using an allele-specific tetraprimer reaction for the genes of the first (CYP1A1 (2 sites)) and second phases of xenobiotic detoxication (GSTM1, GSTT1, GSTP1, GSTM3), DNA repair genes XRCC1, XPD (2 sites), OGG1, as well as NOS1 and MTHFR. The increased risk of disease is associated with a minor variant of CYP1A1 (606G) (p = 0.009; OR = 1.50) and a deletion variant of GSTT1, (p = 0.013, OR = 1.96). Maximum disease risk was observed in carriers of double deletions in GSTT1-GSTM1 (p = 0.017, OR = 2.42). The obtained results are discussed in reference to literary data on the risk of malignant brain tumor formation in children and adults.

• 出版日期2010-12