Antiarrhythmic Effect of Uridine and Uridine-5'-Monophosphate in Acute Myocardial Ischemia

作者：Bul'on V V; Krylova I B^*; Selina E N; Rodionova O M; Evdokimova N R; Sapronov N S; Mironova G D

来源：Bulletin of Experimental Biology and Medicine, 2014, 157(6): 728-731.

DOI：10.1007/s10517-014-2653-3

• myocardium
• ischemia
• arrhythmias
• uridine
• uridine-5 '-monophosphate

Experiments on rats with acute myocardial ischemia accompanied by early postocclusive arrhythmias have shown normalizing, energy-stabilizing, and antiarrhythmic effects of uridine and uridine-5'-monophosphate. The drugs decreased lactate and restored reserves of glycogen and creatine phosphate depleted by ischemia. Uridine and uridine-5'-monophosphate significantly decreased the severity of ventricular arrhythmias. Both drugs reduced the incidence and duration of fibrillation. Uridine -5'-monophosphate demonstrated most pronounced antifibrillatory effectiveness. We hypothesize that the antiarrhythmic effect of the drugs is determined by their capacity to activate energy metabolism.

• 出版日期2014-10