A model-based reconstruction technique for fast dynamic T-1 mapping

作者：Tran Gia Johannes^*; Bisdas Sotirios; Koestler Herbert; Klose Uwe

来源：Magnetic Resonance Imaging, 2016, 34(3): 298-307.

DOI：10.1016/j.mri.2015.10.016

• Dynamic T-1 mapping
• Dynamic parameter mapping
• Model-based reconstruction
• Dynamic contrast-enhanced MRI
• Inversion recovery Look-Locker T-1 mapping

Purpose: To present a technique for dynamic T-1 mapping.
Materials and methods: A recently proposed model-based reconstruction entitled IR-MAP allows T-1 mapping of a single slice from a single radial inversion recovery Look-Locker FLASH acquisition. To enable dynamic T-1 mapping, multiple of these acquisitions are consecutively performed, each followed by a waiting period of 3 s for relaxation. Next, IR-MAP is used to reconstruct an individual T-1 map for each of these acquisitions. Finally, T-1 errors caused by insufficient relaxation between subsequent IR pulses are iteratively corrected.
Results: The functionality of the proposed setup was validated in a phantom and in seven healthy volunteers. Systematic deviations between subsequent T-1 maps originating from insufficient relaxation periods were effectively corrected. Additionally, the approach was successfully applied to monitor the T-1 dynamic in a patient with primary lymphoma after the intravenous injection of contrast agent.
Conclusion: The proposed setup enables dynamic T-1 mapping of a single slice with a spatial resolution of 1.6 mm x 1.6 mm x 3 mm and a temporal resolution of one parameter map every 9 s. It therefore represents a new opportunity to track changes in T-1 over time, as it is desirable in many applications such as dynamic contrast-enhanced MRI.

• 出版日期2016-4