科研之友
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摘要
We present herein results on the PhSeBr-catalyzed addition of thiols to alpha,beta-unsaturated carbonyl compounds under mild conditions to afford regioselectivily beta-mercapto ketones or thioacetals in high yields and selectivity. The reaction was highly controlled by the temperature in which, the 1,4-addition products were obtained when the temperature was -20 degrees C, conversely when the reaction was carried out at reflux, the thioacetals were obtained as a sole product. The developed protocol stands a wide range of functional groups, in which alkyl, benzyl and aryl with neutral, electron deficient and electron rich substituents on the aromatic ring.
- 出版日期2010
