Dietary habits of colorectal neoplasia patients in comparison to their first-degree relativese

作者：Kajzrlikova Ivana Mikoviny^*; Vitek Petr; Chalupa Josef; Dite Petr

来源：World Journal of Gastroenterology, 2014, 20(17): 5025-5030.

DOI：10.3748/wjg.v20.i17.5025

• Colorectal neoplasms
• Family
• Food habits
• Risk factors
• Mass screening

AIM: To compare the dietary habits between colorectal neoplasia patients, their first-degree relatives, and unrelated controls.
METHODS: From July 2008 to April 2011, we collected epidemiological data relevant to colorectal cancer from patients with colorectal neoplasias, their first-degree relatives, and also from a control group consisting of people referred for colonoscopy with a negative family history of colorectal cancer and without evidence of neoplasia after colonoscopic examination. The first-degree relatives were divided into two groups following the colonoscopic examination: (1) patients with neoplasia or (2) patients without neoplasia. Dietary habits of all groups were compared. A. 2 test was used to assess the association between two dichotomous categorical variables.
RESULTS: The study groups consisted of 242 patients with colorectal neoplasias (143 men, 99 women; mean age: 64 +/- 12 years) and 160 first-degree relatives (66 men, 94 women; mean age: 48 +/- 11 years). Fifty-five of the first-degree relatives were found to have a neoplastic lesion upon colonoscopy, while the remaining 105 were without neoplasia. The control group contained 123 individuals with a negative family history for neoplastic lesions (66 men, 57 women; mean age: 54 +/- 12 years). Two hypotheses were tested. In the first, the dietary habits of first-degree relatives with neoplasia were more similar to those of patients with neoplasia, while the dietary habits of first-degree relatives without neoplasia were similar to those of the control group. In the second, no sex-related differences in dietary habits were expected between the particular groups. Indeed, no significant differences were observed in the dietary habits between the groups of patients, controls and first-degree relatives with/without neoplastic lesions. Nevertheless, statistically significant sex-related differences were observed in all groups, wherein women had healthier dietary habits than men.
CONCLUSION: In all groups examined, women had healthier dietary habits than men. Modification of screening guidelines according to sex may improve the efficiency of screening programs.

• 出版日期2014-5-7