A case of cervical cancer expressed three mRNA variant of Hyaluronan-mediated motility receptor

作者：Villegas Ruiz Vanessa; Salcedo Mauricio; Zentella Dehesa Alejandro; Montes de Oca Eden V; Roman Basaure Edgar; Mantilla Morales Alejandra; Davila Borja Victor M; Juarez Mendez Sergio^*

来源：International Journal of Clinical and Experimental Pathology, 2014, 7(5): 2256-2264.

• Cervical cancer
• alternative splicing
• HMMR
• expression

Cervical cancer is the second malignancy in Mexico, little is known about the prognostic factors associated with this disease. Several cellular components are important in their transformation and progression. Alternative mRNA splice is an important mechanism for generating protein diversity, nevertheless, in cancer unknown mRNA diversity is expressed. Hyaluronan-mediated motility receptor (HMMR, RHAMM, CD168) is a family member of proteins, hyaluronan acid dependent, and has been associated with different malignant processes such as: angiogenesis, cell invasiveness, proliferation, metastasis and poor outcome in some tumors. In the present study we identified expression of HMMR in cervical cancer by means of RT-PCR and sequencing. Our results indicate co-expression of two HMMR variants in all samples, and one case expressed three alternative HMMR splice transcripts. These results showed the heterogeneity of mRNA transcripts of HMMR that could express in cancer and the expression of HMMR could be marker of malignancy in CC.

• 出版日期2014
• 单位河北医科大学