A convenient synthesis of ezetimibe analogs as cholesterol absorption inhibitors

作者:Ji, Jian Feng; Zhang, Hui Bin; Huang, Wen Long*; Qian, Hai; Zhou, Jin Pei
来源:Chinese Chemical Letters, 2010, 21(1): 67-69.
DOI:10.1016/j.cclet.2009.08.009

摘要

A convenient method for the synthesis of ezetimibe analogs as cholesterol absorption inhibitors was described. The key step in the synthesis was the intramolecular ring formation through Mitsunobu reaction. Furthermore, a new series of analogs was designed and synthesized.