Preparation, Chemical and Electrical Characterizations of Lipid Nanoparticles Loaded with Dihydroxybenzophenone

作者：Jesus Hierrezuelo; Juana Benavente; Juan Manuel Lopez Romero; de Yuso Maria del Valle Martinez; Enrique Rodriguez Castellon

来源：Medicinal Chemistry, 2012, 8(4): 541-548.

DOI：10.2174/157340612801216238

• Lipid nanoparticles
• 2,4-dihydroxybenzophenone
• homogenizer
• ultrasounds
• SEM
• XPS
• impedance spectroscopy

Lipid nanoparticles loading the sunscreen 2,4-dihydroxybenzophenone (DHB-LNPs) have been prepared by high-pressure homogenization and ultrasound techniques. The combination of both methodologies improves the entrapment efficiency percentage reaching 95%. The morphology of the DHB-LNPs was studied with scanning electron microscopy (SEM) and atomic force microscopy (AFM), while the surface and interior chemical composition was analyzed by X-ray photoelectron spectroscopy (XPS) at different irradiation times. Conductivity of aqueous dispersions of the DHB-LNPs was determined by impedance spectroscopy. A possible DHB-LNPs application related to drug release in a system simulating skin-properties is shown.

• 出版日期2012-7