Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: Implications for treatment of streptococcal toxic shock syndrome

作者：Schrage Birgit; Duan Guowen; Yang Lily P; Fraser John D; Proft Thomas^*

来源：Clinical Infectious Diseases, 2006, 43(6): 743-746.

DOI：10.1086/507037

Eight different batches of intravenous immunoglobulin from 3 different manufacturers were tested for neutralizing activities against all currently known streptococcal super-antigens. Statistically significant variation among different intravenous immunoglobulin preparations (P < .001) and P between individual streptococcal superantigens (P < .0001) was observed. These results might be helpful for optimizing the type and dose of intravenous immunoglobulin used in adjunctive therapy for severe invasive streptococcal disease.

• 出版日期2006-9-15