Microwave-assisted three-component reaction in conventional solvents and ionic liquids for the synthesis of amino-substituted imidazo[1,2-a]pyridines

作者：Mert Balci Fadime; Conrad Juergen; Beifuss Uwe^*

来源：ARKIVOC, 2012, 243-256.

• Multicomponent reactions
• imidazo[1,2-a]pyridines
• microwaves
• ionic liquids
• imidazolium salts
• guanidinium salts

3-Amino-substituted imidazo[1,2-a]pyridines can be prepared with yields up to 98% within a few minutes by microwave-assisted three-component reaction between 2-aminopyridines, aldehydes and isocyanides using montmorillonite as the catalyst and toluene as the solvent. The organic solvent can be replaced by ionic liquids. With guanidinium salts the microwave-assisted reaction can be performed in the absence of any further catalyst.

• 出版日期2012