Antimicrobial activity of the essential oils from the leaves of two morphotypes of Croton cajucara Benth.

作者：Azevedo Mariana M B; Pereira Aline Q; Chaves Francisco C M; Bizzo Humberto R^*; Alviano Celuta S; Alviano Daniela S

来源：Journal of Essential Oil Research, 2012, 24(4): 351-357.

DOI：10.1080/10412905.2012.692902

• antimicrobial activity
• essential oil composition
• Croton cajucara
• Candida albicans
• Staphylococcus aureus
• linalool
• 7-hydroxycalamenene

Croton cajucara Benth. (Euphorbiaceae) is a shrub native to Amazon region and locally known as sacaca. Two morphotypes are known, namely white %26apos;sacaca%26apos; and red %26apos;sacaca%26apos;. The essential oils from the leaves of these morphotypes are rich in linalool and 7-hydroxycalamenene, respectively. The effectiveness of the oils from forty individuals from a germplasm bank regarding the antimicrobial activity against Staphylococcus aureus and Candida albicans was investigated by drop diffusion (or agar diffusion) method. Expressive inhibition zones for both microorganisms tested were observed. Essential oils rich in 7-hydroxycalamenene were more effective against S. aureus while linalool-rich essential oils acted inhibiting C. albicans. The minimal inhibitory (MIC) and microbicidal concentrations of the main constituents of the oils were also determined, using broth dilution assay. It was observed that isolated 7-hydroxycalamenene presented high bactericidal activity, with a MIC of 0.3 mu g/mL, while for fungicidal activity a MIC of 45 mu g/mL was recorded. For S. aureus, the isolated 7-hydroxycalamenene was more active than the whole oil, whereas the linalool-rich essential oil presented higher bactericide activity than pure linalool. For C. albicans, however, pure linalool was more active than the whole essential oil.

• 出版日期2012