Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries

作者：Rudd Kristina E; Seymour Christopher W; Aluisio Adam R; Augustin Marc E; Bagenda Danstan S; Beane Abi; Byiringiro Jean Claude; Chang Chung Chou H; Colas L Nathalie; Day Nicholas P J; De Silva Pubudu; Dondorp Arjen M; Dunser Martin W; Faiz M Abul; Grant Donald S; Haniffa Rashan; Nguyen Van Hao; Kennedy Jason N; Levine Adam C; Limmathurotsakul Direk; Mohanty Sanjib; Nosten Francois; Papali Alfred; Patterson Andrew J; Schieffelin John S; Shaffer Jeffrey G

来源：Journal of the American Medical Association, 2018, 319(21): 2202-2211.

DOI：10.1001/jama.2018.6229

IMPORTANCE The quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) score has not been well-evaluated in low- and middle-income countries (LMICs).
OBJECTIVE To assess the association of qSOFA with excess hospital death among patients with suspected infection in LMICs and to compare qSOFA with the systemic inflammatory response syndrome (SIRS) criteria.
DESIGN, SETTINGS, AND PARTICIPANTS Retrospective secondary analysis of 8 cohort studies and 1 randomized clinical trial from 2003 to 2017. This study included 6569 hospitalized adults with suspected infection in emergency departments, inpatient wards, and intensive care units of 17 hospitals in 10 LMICs across sub-Saharan Africa, Asia, and the Americas.
EXPOSURES Low (0), moderate (1), or high (>= 2) qSOFA score (range, 0 [best] to 3 [worst]) or SIRS criteria (range, 0 [best] to 4 [worst]) within 24 hours of presentation to study hospital.
MAIN OUTCOMES AND MEASURES Predictive validity (measured as incremental hospital mortality beyond that predicted by baseline risk factors, as a marker of sepsis or analogous severe infectious course) of the qSOFA score (primary) and SIRS criteria (secondary).
RESULTS The cohorts were diverse in enrollment criteria, demographics (median ages, 29-54 years; males range, 36%-76%), HIV prevalence (range, 2%-43%), cause of infection, and hospital mortality (range, 1%-39%). Among 6218 patients with nonmissing outcome status in the combined cohort, 643 (10%) died. Compared with a low or moderate score, a high qSOFA score was associated with increased risk of death overall (19% vs 6%; difference, 13% [95% Cl, 11%-14%]; odds ratio, 3.6 [95% Cl, 3.0-4.2]) and across cohorts (P < .05 for 8 of 9 cohorts). Compared with a low qSOFA score, a moderate qSOFA score was also associated with increased risk of death overall (8% vs 3%; difference, 5% [95% Cl, 4%-6%]; odds ratio, 2.8 [95% Cl, 2.0-3.91), but not in every cohort (P < .05 in 2 of 7 cohorts). High, vs low or moderate, SIRS criteria were associated with a smaller increase in risk of death overall (13% vs 8%; difference, 5% [95% Cl, 3%-6%]; odds ratio, 1.7 [95% Cl, 1.4-2.0]) and across cohorts (P < .05 for 4 of 9 cohorts). qSOFA discrimination (area under the receiver operating characteristic curve [AUROC], 0.70 [95% Cl, 0.68-0.72]) was superior to that of both the baseline model (AUROC, 0.56 [95% Cl, 0.53-0.58; P < .001) and SIRS (AUROC, 0.59 [95% CI, 0.57-0.62]; P < .001).
CONCLUSIONS AND RELEVANCE When assessed among hospitalized adults with suspected infection in 9 LMIC cohorts, the qSOFA score identified infected patients at risk of death beyond that explained by baseline factors. However, the predictive validity varied among cohorts and settings, and further research is needed to better understand potential generalizability.

• 出版日期2018-6-5