ANALYSIS OF EXPRESSION OF AIF AND PARP-1 IN CANCEROGENESIS OF HPV-POSITIVE CERVIX

作者：Warowicka Alicja^*; Kwasniewska Anna; Sobieraj Marcin; Godzicka Jozefiak Anna

来源：Bulletin of the Veterinary Institute in Pulawy, 2011, 55(3): 367-370.

• women
• human papillomaviruses
• cervical cancer
• PARP-1
• AIF

The mRNA expression of AIF and PARP-1 in HPV negative non-tumour epithelial cells and HPV-positive cervical cancer cells using the real-time PCR method was examined. An increased level of AIF and PARP-1 mRNA in cervical cancer cells in comparison to normal epithelial cells was demonstrated. These results suggest that changes in the mRNA expression level of AIF and PARP-1 might be involved in cervical cancer development. The analysis of these two factors may represent a new molecular tool for cervical cancer prevention in women with HPV persistent infection.

• 出版日期2011