Difference in number of loci of swine leukocyte antigen classical class I genes among haplotypes

作者：Tanaka Matsuda Maiko; Ando Asako; Rogel Gaillard Claire; Chardon Patrick; Uenishi Hirohide^*

来源：Genomics, 2009, 93(3): 261-273.

DOI：10.1016/j.ygeno.2008.10.004

• Immunogenetics
• Major histocompatibility complex (MHC)
• Copy number variance
• Sus scrofa
• Genomic structure
• Molecular evolution

The Structure of the entire genomic region of swine leukocyte antigen (SLA)-the porcine major histocompatibility complex-was recently elucidated in a particular haplotype named Hp-1.0 (H01). However, it has been suggested that there are differences in the number of loci of SLA genes, particularly classical class I genes, among haplotypes. To clarify the between-haplotype copy number variance in genes of the SLA region, we sequenced the genomic region carrying SLA classical class I genes on two different haplotypes, revealing increments of up to six in the number of classical class I genes in a single haplotype. All of the SLA-1(-like) (SLA-1 and newly designated SLA-12) and SLA-3 genes detected in the haplotypes thus analyzed were transcribed in the individual. The process by which duplication of SLA classical class I genes was likely to have occurred was interpreted from an analysis of repetitive sequences adjacent to the duplicated class I genes.

• 出版日期2009-3
• 单位中国地震局