科研之友
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摘要
Background: The aim of the study was to evaluate the association of immunoglobulin G type of autoantibodies to oxidized low-density lipoprotein (oxLDL-IgG) and oxLDL-IgM with the progression of esophageal squamous cell carcinoma (ESSC). @@@ Methods: Residents from Feicheng, China aged 40 to 69 years were screened for esophageal lesions in a screening program conducted during the period of January 2008 to December 2006. There were 33 controls with normal esophageal squamous epithelium cells, 37 patients with basal cell hyperplasia, 47 with esophageal squamous cell dysplasia, and 43 with ESCC. All the participants were diagnosed by biopsy and histopathological examination. Adiponectin, oxidized low-density lipoprotein (oxLDL), autoantibodies against oxLDL (oxLDL-ab), OxLDL-IgG, and OxLDL-IgM were determined by enzyme linked immunosorbent assay (ELISA). Total cholesterol, High-density lipoprotein (HDL), triglyceride, serum albumin, and blood pressure were co-estimated. Analysis of covariance for lipid levels was used to control the influence of covariates. @@@ Results: The level of oxLDL-IgM increased gradually along with esophageal carcinoma progression. The oxLDL-IgM levels in the ESCC group were the highest after possible covariates were controlled. Binary logistic regression showed that oxLDL-IgM had a positive correlation with the development of esophageal carcinoma, while oxLDL and oxLDL-ab had a negative correlation with ESSC. No significant association between the levels of oxLDL-IgG and adiponectin and the different stages of ESSC was observed. @@@ Conclusion: The present study shows that the decreased oxLDL and oxLDL-ab and the elevated oxLDL-IgM serum levels may relate to the development and progression of ESSC.
