South-East Asia bovine populations and the Japanese cattle breeds do not harbour the E211K variant of the PRNP

作者：Msalya George^*; Shimogiri Takeshi; Matsumoto Yuichiro; Okamoto Shin; Kawabe Kotaro; Maeda Yoshizane

来源：Italian Journal of Animal Science, 2014, 13(1): 2996.

DOI：10.4081/ijas.2014.2996

• BSE
• Cattle breeds
• E211K
• PRNP
• Populations

An important outcome of intensive worldwide Bovine spongiform encephalopathy (BSE) obtained with the surveillance by The National Creutzfeldt-Jakob Disease Surveillance Unit (http://www.cjd.ed.ac.uk/figures.htm), has been the detection of atypical BSE in cattle. The discovery of a prion protein gene (PRNP) E211K variant in an atypical BSE case is particularly remarkable because it is analogous to the most common pathogenic mutation in humans (E200K), which causes hereditary Creutzfeldt-Jakob disease (CJD). Knowledge of the distribution and frequency of PRNP E211K variants in cattle populations is critical for understanding and managing atypical BSE. This study was carried out to investigate the prevalence of the E211K variant in the South-East Asia bovine populations and in the Japanese cattle breeds. It was discovered that E211K variant was monomorphic for a G allele and the GG genotype in the 745 animals analyzed in this study. Therefore, neither the Bos indicus nor the Bos taurus animals analyzed are presently known to harbor the 211K variant predicting that the number of carriers for this variant will also be vanishingly low.

• 出版日期2014