Mitochondrial Injury and Protection in Ischemic Pre- and Postconditioning

作者：Di Lisa Fabio^*; Canton Marcella; Carpi Andrea; Kaludercic Nina; Menabo Roberta; Menazza Sara; Semenzato Martina

来源：Antioxidants and Redox Signaling, 2011, 14(5): 881-+.

DOI：10.1089/ars.2010.3375

Mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability, yet a mild degree of mitochondrial dysfunction appears to underlie cardioprotection against injury caused by postischemic reperfusion. This review is focused on two major mechanisms of mitochondrial dysfunction, namely, oxidative stress and opening of the mitochondrial permeability transition pore. The formation of reactive oxygen species in mitochondria will be analyzed with regard to factors controlling mitochondrial permeability transition pore opening. Finally, these mitochondrial processes are analyzed with respect to cardioprotection afforded by ischemic pre- and postconditioning. Antioxid. Redox Signal. 14, 881-891.

• 出版日期2011-3