Dutasteride, who is it more effective for? Second to fourth digit ratio and the relationship with prostate volume reduction by dutasteride treatment

作者：Kim Tae Beom; Oh Jin Kyu; Kim Khae Hawn; Jung Han; Yoon Sang Jin; Lee Min Sung; Kim Soo Woong^*

来源：BJU International, 2012, 110(11C): E857-E863.

DOI：10.1111/j.1464-410X.2012.11343.x

• benign prostatic hyperplasia
• digit ratio dutasteride
• prostate volume

OBJECTIVE
To investigate the relationship between second to fourth digit ratio (hereafter the digit ratio) and prostate volume reduction by dutasteride treatment.
PATIENTS AND METHODS
A total of 142 men aged >= 40 years with a clinical diagnosis of benign prostatic hyperplasia and an enlarged prostate (prostate volume >= 30 mL) were prospectively enrolled.
Before prostate-specific antigen (PSA) level determination and transrectal ultrasonography (TRUS), the lengths of the second and fourth digits of the right hand were measured by an investigator using a digital vernier calliper.
Using TRUS, pre- and post-treatment prostate volume (PV1 and PV2) were measured by an uroradiologist who was unaware of finger lengths. We investigated the change in prostate volume and PSA level at least 6 months after the initiation of dutasteride therapy.
RESULTS
When the patients were divided into two groups according to digit ratio (A: digit ratio <0.95, n = 71; B: digit ratio >= 0.95, n = 71), there was a greater reduction in prostate volume in group B compared to group A (PV2 -PV1: -9.4 mL vs -13.2 mL, P = 0.042; [PV2 -PV1]/PV1: -17.5% vs -24.5%, P = 0.027; [PV2 -PV1]/duration: -1.1 mL/month vs-1.6 mL/month, P = 0.041; [PV2-PV1]/PV1/duration: -2.0%/month vs-3.0%/month, P = 0.016).
Significant negative correlations were found between the digit ratio and reduction rate ([PV2 -PV1] /duration: r = -0.165, P = 0.049; [PV2 -PV1] /PV1/duration: r = -0.191, P = 0.023).
CONCLUSIONS
Patients with higher digit ratios respond well to dutasteride treatment.
The results obtained in the present study suggest that the digit ratio is a predictor of the response to dutasteride treatment.

• 出版日期2012-12