AMH levels at central precocious puberty and premature thelarche: is it a parameter?

作者：Sahin Nursel Muratoglu^*; Kinik Sibel Tulgar; Tekindal Mustafa Agah; Bayraktar Nilufer

来源：Journal of Pediatric Endocrinology & Metabolism, 2015, 28(11-12): 1351-1356.

DOI：10.1515/jpem-2014-0521

• AMH
• precocious puberty
• premature thelarche

Background: The possible difference of antimllrin hormone (AMH) levels at central precocious puberty (CPP) and premature thelarche (PT) has not been properly evaluated.
Objective/hypothesis: By evaluating AMH levels in girls with diagnosed CPP and PT, we aim to show the change of AMH levels at the pubertal onset.
Subjects: Sixty-five girls who have breast development before the age of 8 years and 25 healthy girls were enrolled in the study.
Methods: The subjects were divided into two groups as CPP and PT, according to results of GnRH test. AMH levels were determined in the two groups.
Results: The mean AMH levels of the CPP group were significantly lower than those in the PT group (13.57 +/- 9.85 pmol/L and 58.42 +/- 12.78 pmol/L, respectively, p=0.022).
Conclusion: These results suggest that the AMH levels decrease in the duration of the hypothalamus-pituitaryovarian axis activation. We thought that AMH might/may be a marker for distinguishing between CPP and PT.

• 出版日期2015-11