A targeted drug delivery system based on carbon nanotubes loaded with lobaplatin toward liver cancer cells

作者：Yu, Shiping^*; Li, Qiang; Wang, Junli; Du, Jinglei; Gao, Yuduan; Zhang, Li; Chen, Lin; Yang, Yongzhen^*; Liu, Xuguang

来源：Journal of Materials Research, 2018, 33(17): 2565-2575.

DOI：10.1557/jmr.2018.197

• carbon nanotubes
• lobaplatin
• liver cancer cell
• anticancer
• target

To eliminate the toxic effect of chemotherapy drug of lobaplatin (LBP) on body tissue in liver cancer therapy, this work prepared a nanodrug carrier based on polyethylene glycol-modified carbon nanotubes (PEG-CNTs) and then constructed a targeted drug delivery system (LBP-PEG-CNTs) by loading LBP on PEG-CNTs. Fluorescein isothiocyanate (FITC) was used to label PEG-CNTs to observe the cellular uptake of PEG-CNTs. In addition, the inhibitions of LBP-PEG-CNTs on HepG(2) cells were investigated. The results show that the FITC-labeled PEG-CNTs have good cell penetrability; meanwhile, LBP-PEG-CNTs have good stability, pH-controlled release property, and high inhibition rate on HepG(2) cells. To be specific, 80% of LBP is released under physiological conditions of liver cancer cells at pH 5.0, and LBP-PEG-CNTs show a high inhibition rate of 77.86% on HepG(2) cells, demonstrating that they have targeted, pH-controlled release and inhibition properties on HepG(2) cells.

• 出版日期2018-9-14
• 单位山西医科大学第二医院; 太原理工大学