Al-26 incorporation into the brain of rat fetuses through the placental barrier and subsequent metabolism in postnatal development

作者：Yumoto Sakae^*; Nagai Hisao; Kakimi Shigeo; Matsuzaki Hiroyuki

来源：Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms , 2010, 268(7-8): 1328-1330.

DOI：10.1016/j.nimb.2009.10.165

• Al-26
• Aluminium toxicity
• AMS
• Placental barrier
• Alzheimer's disease

Aluminium (Al) inhibits prenatal and postnatal development of the brain. We used Al-26 as a tracer, and measured Al-26 incorporation into rat fetuses through the placental barrier by accelerator mass spectrometry (AMS). From day 15 to day 18 of gestation, (AlCl3)-Al-26 was subcutaneously injected into pregnant rats. Considerable amounts of Al-26 were measured in the tissues of newborn rats immediately after birth. The amounts of Al-26 in the liver and kidneys decreased rapidly during postnatal development. However, approximately 15% of Al-26 incorporated into the brain of fetuses remained in the brain of adult rats 730 days after birth.

• 出版日期2010-4