Molecular Drug Susceptibility Testing and Genotyping of Mycobacterium leprae Strains from South America

作者：Singh Pushpendra; Busso Philippe; Paniz Mondolfi Alberto; Aranzazu Nacarid; Monot Marc; Honore Nadine; Fernandes Belone Andrea de Faria; Virmond Marcos; Esther Villarreal Olaya Maria; Rivas Carlos; Cole Stewart T^*

来源：Antimicrobial Agents and Chemotherapy, 2011, 55(6): 2971-2973.

DOI：10.1128/AAC.00201-11

Possible drug resistance in Mycobacterium leprae strains from Venezuela and three other South American countries was surveyed by molecular methods. None of the 230 strains from new leprosy cases exhibited drug resistance-associated mutations. However, two of the three strains from relapsed cases contained dapsone resistance mutations, and one strain also harbored a rifampin resistance mutation. Single nucleotide polymorphism analysis of these strains revealed five subtypes: 3I (73.8%), 4P (11.6%), 1D (6.9%), 4N (6%), and 4O (1.7%).

• 出版日期2011-6