Using injection molding and reversible bonding for easy fabrication of magnetic cell trapping and sorting devices

作者：Royet David^*; Heriveaux Yoann; Marchalot Julien; Scorretti Riccardo; Dias Andre; Dempsey Nora M; Bonfim Marlio; Simonet Pascal; Frenea Robin Marie

来源：Journal of Magnetism and Magnetic Materials, 2017, 427: 306-313.

DOI：10.1016/j.jmmm.2016.10.102

• Cell trapping
• Magnetic PDMS composites
• Injection
• Reversible bonding
• Continuous flow sorting

Magnetism and microfluidics are two key elements for the development of inexpensive and reliable tools dedicated to high-throughput biological analysis and providing a large panel of applications in domains ranging from fundamental biology to medical diagnostics. In this work, we introduce a simple protocol, relying on injection molding and reversible bonding for fabrication of magnetic cell trapping and sorting devices using only standard soft-lithography equipment. Magnetic strips or grids made of Polydimethylsiloxane (PDMS) doped with hard (NdFeB) or soft (carbonyl iron) magnetic powders were integrated at the bottom of whole PDMS chips. Preliminary results show the effective deviation/trapping of magnetic beads or magnetically-labeled bacteria as the sample flows through the microchannel, proving the potential of this rapid prototyping approach for easy fabrication of magnetic cell sorters.

• 出版日期2017-4-1