Albumin coatings by alternating current electrophoretic deposition for improving corrosion resistance and bioactivity of titanium implants

作者：Hoehn Sarah; Braem Annabel; Neirinck Bram; Virtanen Sannakaisa^*

来源：Materials Science & Engineering C-Materials for Biological Applications, 2017, 73: 798-807.

DOI：10.1016/j.msec.2016.12.129

• Ti6AI4V
• DMEM
• Fetal calf serum
• Electrophoretic deposition
• Alternating current
• Bovine serum albumin

Although Ti alloys are generally regarded to be highly corrosion resistant, inflammatoly conditions following surgery can instigate breakdown of the TiO2 passivation layer leading to an increased metal ion release. Furthermore proteins present in the surrounding tissue will readily adsorb on a titanium surface after implantation. In this paper alternating current electrophoretic deposition (AC-EPD) of bovine serum albumin (BSA) on T16A14V was investigated in order to increase the corrosion resistance and control the protein adsorption capability of the implant surface. The Ti6AI4V surface was characterized with SEM, XPS and ToF-SIMS after long-term immersion tests under physiological conditions and simulated inflammatory conditions either in Dulbecco's Modified Eagle Medium (DMEM) or DMEM supplemented with fetal calf serum (FCS). The analysis showed an increased adsorption of amino acids and proteins from the different immersion solutions. The BSA coating was shown to prevent selective dissolution of the vanadium (V) rich beta-phase, thus effectively limiting metal ion release to the environment. Electrochemical impedance spectroscopy measurements confirmed an increase of the corrosion resistance for BSA coated surfaces as a fttnction of immersion time due to the time-dependent adsorption of the different amino acids (from DMEM) and proteins (from FCS) as observed by ToF-SIMS analysis.

• 出版日期2017-4-1