Antimicrobial films based on cellulose-derived hydrocolloids. A synergetic effect of host-guest interactions on quality and functionality

作者：Rutenberg Roi; Bernstein Solange; Paster Nachman; Fallik Eli; Poverenov Elena^*

来源：Colloids and Surfaces B: Biointerfaces , 2016, 137: 138-145.

DOI：10.1016/j.colsurfb.2015.06.022

• Bio-active hydrocolloids
• Controlled release
• beta-Cyclodextrin
• Propionic acid
• Cellulose derivatives
• Antimicrobial

A series of active films based on biodegradable cellulose-derived hydrocolloids capable of controlled release of antimicrobial propionic acid (PA) was prepared.
beta-Cyclodextrin (beta-CD), usually used for encapsulation of lipophilic compounds, was utilized in this research to host the hydrophilic PA. It was found that addition of beta-CD to the film forming solutions notably enhanced the hydrocolloid matrix capacity and resulted in up to a ten-fold increase in the amount of uploaded PA. In addition, beta-CD resulted in a two-fold prolongation of the effective PA release duration. beta-CD alone caused undesired effects on the physical, mechanical and morphological properties of the hydrocolloid films. Interestingly, when beta-CD was combined with PA in the film formulation, its undesired effects were significantly subdued. The antifungal activity of the films was demonstrated on fresh harvested wheat grains. Films containing beta-CD and PA were found to be effective in preventing fungal growth on wheat grains. Thus, incorporation of beta-CD and PA in hydrocolloids matrices demonstrated a synergetic effect and resulted in the formation of biodegradable active films that benefit good physical and mechanical properties, high active agent content, prolonged release ability and effective antimicrobial properties.

• 出版日期2016-1-1