An environmentally benign approach for the synthesis of 3,4,5-trisubstituted 2-aminofurans under solvent-free conditions via isocyanide-based multicomponent approach

作者：Shah Tariq A; Ahmad Zubair; Rath N P; Muneer M^*

来源：Tetrahedron Letters, 2016, 57(24): 2638-2641.

DOI：10.1016/j.tetlet.2016.05.007

• Multicomponent
• Dibenzoylacetylene
• 2-Aminofurans
• Isocyanide
• Solvent-free

An efficient solvent-free procedure for the synthesis of 3,4,5-trisubstituted 2-aminofurans has been developed via a multicomponent strategy by the solid state condensation of finely grounded dibenzoylacetylene and aromatic aldehydes in the presence of isocyanides at room temperature. Clean reaction profile, easy work-up procedure, non-chromatographic purification technique, short reaction times, high yields, and solvent-free reaction conditions are the remarkable advantages of this procedure. Single crystal X-ray diffraction has been established for four structures.

• 出版日期2016-6-15