Comparison of Results of Transcatheter Aortic Valve Implantation in Patients With Severely Stenotic Bicuspid Versus Tricuspid or Nonbicuspid Valves

作者：Costopoulos Charis; Latib Azeem; Maisano Francesco; Testa Luca; Bedogni Francesco; Buchanan Louise; Naganuma Toru; Sticchi Alessandro; Sato Katsumasa; Miyazaki Tadashi; Figini Filippo; Giannini Francesco; Taramasso Maurizio; Naim Charbel; Carlino Mauro; Chieffo Alaide; Montorfano Matteo; Alfieri Ottavio; Colombo Antonio^*

来源：American Journal of Cardiology, 2014, 113(8): 1390-1393.

DOI：10.1016/j.amjcard.2014.01.412

Data on transcatheter aortic valve implantation (TAVI) for severe bicuspid aortic valve (BAY) stenosis and how this compares to that for tricuspid aortic valve (TAV) stenosis are limited. Twenty-one consecutive patients with BAV were treated with the Edwards or Core Valve bioprosthesis from November 2007 to December 2012 at San Raffaele Scientific Institute and Clinical Institute S. Ambrogio, Milan, Italy. Results were compared with a cohort of patients with TAV (n=447) treated with the same bioprostheses over the same period. Procedural 1- and 12-month outcomes were examined as defined by the Valve Academic Research Consortium criteria. Patients with BAY were younger (76.7 +/- 7.1 vs 79.8 +/- 7.4 years, p=0.06) and with a larger aortic annulus (25.0 +/- 1.8 vs 23.6 +/- 2.1 mm, p=0.01). Device success (85.7% vs 94.4%, p=0.10) was lower in patients with BAY. Although the 30-day composite safety end point (23.8% vs 21.0%, p=0.76) was similar between the 2 groups, mortality rate at 30 days was higher (14.2% vs 3.6%, p=0.02) in the BAY group. Cardiovascular mortality at 1 year did not differ significantly between the 2 groups (10.5% vs 7.4%, p=0.62). In conclusion, transcatheter aortic valve implantation in high surgical risk patients with severe BAY stenosis appears to be feasible with mid-term cardiovascular mortality similar to that for patients with TAV. Early survival and device success, however, were lower for patients with BAY demonstrating that further studies are required to identify which subset of patients with BAY is best suited for transcatheter treatment.

• 出版日期2014-4-15