Aging-associated B7-DC+ B cells enhance anti-tumor immunity via Th1 and Th17 induction

作者：Tomihara Kei; Shin Takako; Hurez Vincent J; Yagita Hideo; Pardoll Drew M; Zhang Bin; Curiel Tyler J; Shin Tahiro

来源：Aging Cell, 2012, 11(1): 128-138.

DOI：10.1111/j.1474-9726.2011.00764.x

• B7-DC
• PD-L2
• co-stimulation
• B cell
• cytotoxic T lymphocyte
• antitumor immunity
• Th17

Because most patients with cancer are aged and because immunological functions are altered during aging, it is important to account for aging-associated immunological alterations in the design of new cancer immunotherapies. We thus compared immune populations in young and aged mice and found that B7-DC+ (PD-L2/CD273) B cells, a minor population in young mice, were significantly increased in aged mice. Induction of both Th1 and Th17 cells was significantly augmented by B7-DC+ B cells from aged mice, and this effect was blocked with anti-B7-DC antibodies in vitro and in vivo. Moreover, retardation of tumor growth in aged mice was largely B7-DC dependent. Tumor growth in young mice was significantly inhibited by immunization with B7-DC+ B cells from aged mice owing to increased induction of tumor antigen-specific cytotoxic T lymphocytes. These data indicate that B7-DC+ B cells could play an important role in aging-associated cancer immunopathology as well as in other aging-associated diseases and further suggest that B7-DC+ B cells have potential for future cancer immunotherapy.

• 出版日期2012-2