科研之友
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摘要
Inositol phosphate derivatives are usually synthesized by repeated protection-deprotection procedures, necessitating development of an independent synthetic route for each inositol derivative. Herein, a synthetic precursor for all regioisomers of inositol phosphate is reported. A cycloadduct obtained by the Diels-Alder reaction of trans-1-methoxy-3-trimethylsilyloxybuta-1,3-diene and methyl vinyl ketone was converted into an inositol derivative by sequential introduction and immediate protection of hydroxy groups. Thus, the six hydroxy groups of the obtained inositol derivative are differentiated by different protective groups that are cleavable under independent conditions. This would enable us to prepare all regioisomers of inositol phosphate derivative.
- 出版日期2012-3
