Are high-sensitivity cardiac troponin I values stable between preoperative visit and day of non-cardiac surgery?

作者：Samaha Eslam; Helwani Mohammad A; Brown Jamie C; Brown Frank; Jaffe Allan S; Scott Mitchell G; Nagele Peter^*

来源：Clinical Biochemistry, 2018, 52: 171-172.

DOI：10.1016/j.clinbiochem.2017.11.014

Background: It is unclear if cardiac troponin values are stable in patients prior to undergoing non-cardiac surgery, or if they tend to rise towards the day of surgery.
Methods: In this small pilot study (n = 18) among patients with cardiac risk undergoing non-cardiac surgery, we determined if high-sensitivity cardiac troponin I (hscTnI) changes between the preoperative clinic visit and the day of surgery. HscTnI was measured on an Abbott Architect STAT (Abbott Laboratories, USA) platform.
Results: The mean duration between preoperative clinic visit and day of surgery was 8.7 +/- 2.8 (SD) days. Median hscTnI was 3.4 ng/L [2.0-4.8, IQR] at the preoperative visit and 2.8 ng/L [2.3-4.4] on the day of surgery (mean difference - 0.24 ng/L, 95% CI - 0.73 to 0.24 ng/L, p = 0.30). Only one patient had a large change (> 50%) along with symptoms.
Discussion: Evidence from this small study suggests that cardiac troponin values are stable in most high-risk patients, absent clinical events, within 10 days prior to non-cardiac surgery.

• 出版日期2018-2