The Prophylactic Use of a Topical Scar Gel Containing Extract of Allium Cepae, Allantoin., and Heparin Improves Symptoms and Appearance of Cesarean-Section Scars Compared With Untreated Scars

作者：Ocampo Candiani Jorge^*; Vazquez Martinez Osvaldo T; Iglesias Benavides Jose Luis; Buske Kristin; Lehn Annette; Acker Clemens

来源：Journal of Drugs in Dermatology, 2014, 13(2): 176-182.

Background: Abdominal Cesarean sections (C-sections) are frequently associated with an increased risk of excessive or unpleasant scarring. A topical scar gel containing extract of Allium cepae, allantoin and heparin (Contractubex; Merz Pharmaceuticals GmbH, Germany), has shown efficacy in improving the appearance of various scar types.
Objective: To investigate the efficacy of the topical scar gel, Contractubex, in the early treatment of C-section scars.
Materials & Methods: A total of 61 females, aged years, who had given birth by elective C-section for the first time within the last 5-10 days, were included in this prospective, randomized, single-center study. Patients were advised to apply the topical scar gel twice daily (treatment group), or received no treatment (control group). Efficacy was evaluated at 6 and 12 weeks after a baseline visit using the Patient and Observer Scar Assessment Scale (POSAS), a validated scar assessment tool comprised of a Patient Scale and an Observer Scale.
Results: Analysis revealed a significant change in the POSAS Patient Scale total score, with a 14.2% improvement in the treatment group compared with a decline of similar magnitude (-14.8%) in the control group at week 6. Significant improvements were also seen for POSAS Patient Scale sub-items in the treatment group compared with the control group for scar color (13.6% vs 18.5%, respectively, P=0.0284), stiffness (12.5% vs -34.6%, respectively, P=0.0029), and irregularity (29.4% vs -46.2%, respectively, P=0.0140) after 6 weeks of treatment. No significant changes were observed for the POSAS Observer Scale total score or its sub-items after treatment with the topical scar gel, although there was a strong overall trend in favor of the treatment group. No significant adverse events were observed during the study.
Conclusion: Contractubex represents an efficacious and well-tolerated preventative treatment that rapidly and significantly improves the color, stiffness and irregularity of C-section scars.

• 出版日期2014-2