Drosophila ubiquitin E3 ligase dSmurf is required for synapse remodeling and axon pruning by glia

作者:Chen, Changyan; Yin, Shuai; Cao, Wenze; Ho, Margaret S.*
来源:Journal of Genetics and Genomics, 2017, 44(1): 67-70.
DOI:10.1016/j.jgg.2016.10.007

摘要

<正>Animal behaviors and higher-order functions rely on complex neural circuits built by synaptic connections(synapses)to deliver messages among different brain cells.As the major mediator in the nervous system,neurons communicate via synapses,which undergo constant structural remodeling with strict regulation.It is